abstract：:Long non-coding RNA (lncRNA) H19 is associated with inflammatory diseases, but the molecular mechanism of H19 in the inflammatory process of ankylosing spondylitis (AS) is unclear. Here, we investigated the role of H19 and its downstream molecules in the inflammation of AS by microarray analysis, qRT-PCR, western blot...

journal_title：Molecular therapy. Nucleic acids

authors： Zhang X,Ji S,Cai G,Pan Z,Han R,Yuan Y,Xu S,Yang J,Hu X,Chen M,Wu M,Ma Y,Deng J,Gao X,Guan S,Xu S,Shuai Z,Laslett L,Pan F

更新日期：2020-03-06 00:00:00

abstract：:Methyltransferase-like 3 (METTL3) is the main enzyme for N6-methyladenosine (m6A)-based methylation of RNAs and it has been implicated in many biological and pathophysiological processes. In this study, we aimed to explore the potential involvement of METTL3 in osteoblast differentiation and decipher the underlying ce...

journal_title：Molecular therapy. Nucleic acids

authors： Yan G,Yuan Y,He M,Gong R,Lei H,Zhou H,Wang W,Du W,Ma T,Liu S,Xu Z,Gao M,Yu M,Bian Y,Pang P,Li X,Yu S,Yang F,Cai B,Yang L

更新日期：2020-03-06 00:00:00

abstract：:Glioblastoma is the most common malignant primary brain tumor among adults and one of the most lethal cancers. It is characterized by the deregulation of signaling pathways involving proliferation, growth, survival, and other factors. MicroRNAs (miRNAs) play a role in the regulation of genes by affecting the 3' untran...

journal_title：Molecular therapy. Nucleic acids

authors： Moradimotlagh A,Arefian E,Rezazadeh Valojerdi R,Ghaemi S,Jamshidi Adegani F,Soleimani M

更新日期：2020-03-06 00:00:00

abstract：:Inflammatory mediators play a key role in the pathogenesis of acute respiratory distress syndrome (ARDS). In this study, we aimed to explore the involvement of the Kcnq1 opposite strand/antisense transcript 1 (Kcnq1ot1)/miR-381-3p/E26 transformation-specific proto-oncogene 2 (ETS2) axis in inflammation of lipopolysacc...

journal_title：Molecular therapy. Nucleic acids

authors： Jiang X,Yu M,Zhu T,Lou L,Chen X,Li Q,Wei D,Sun R

更新日期：2020-03-06 00:00:00

abstract：:Exosomes mediate cell-cell crosstalk in cancer progression by transferring a variety of biomolecules, including long noncoding RNAs (lncRNAs). Long non-coding RNA urothelial carcinoma-associated (UCA1) is a well-known lncRNA associated with the development and progression of various cancers, including colorectal cance...

journal_title：Molecular therapy. Nucleic acids

authors： Luan Y,Li X,Luan Y,Zhao R,Li Y,Liu L,Hao Y,Oleg Vladimir B,Jia L

更新日期：2020-03-06 00:00:00

abstract：:F-box and WD repeat domain-containing protein 7 (FBW7) has been documented to be implicated in nuclear factor κB (NF-κB) signaling and inflammation, but its role in the pathogenesis of inflammatory bowel disease (IBD) remains unknown. FBW7 was increased both in colon tissues from IBD patients and trinitrobenzene sulph...

journal_title：Molecular therapy. Nucleic acids

authors： Meng Q,Wu W,Pei T,Xue J,Xiao P,Sun L,Li L,Liang D

更新日期：2020-03-06 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Accumulating evidence reveals the significance of long non-coding RNAs (lncRNAs) in various cancers. The current study aimed to evaluate the role of GATA6 antisense RNA 1 (GATA6-AS1) in the epithelial-mesenchymal transition (EMT) and ...

journal_title：Molecular therapy. Nucleic acids

authors： Li ZT,Zhang X,Wang DW,Xu J,Kou KJ,Wang ZW,Yong G,Liang DS,Sun XY

更新日期：2020-03-06 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) are hypoxia-inducible secreted proteins to promote angiogenesis, in which VEGF-A is an important molecule that binds and activates VEGF receptor-1 (VEGFR-1) and VEGFR-2. In this study, two DNA aptamers, Apt01 and Apt02, were successfully isolated by alternating consecutive s...

journal_title：Molecular therapy. Nucleic acids

authors： Yoshitomi T,Hayashi M,Oguro T,Kimura K,Wayama F,Furusho H,Yoshimoto K

更新日期：2020-03-06 00:00:00

abstract：:Recent studies reported that DNA methylation was involved in retinal cell death. Methyl-CpG binding domain protein 2 (Mbd2) is one of the DNA methylation readers. Its role and mechanism of regulation remain unclear. The ischemia/reperfusion (I/R) model in mice primary culture retinal ganglion cells (RGCs) and Mbd2 kno...

journal_title：Molecular therapy. Nucleic acids

authors： Ge Y,Zhang R,Feng Y,Li H

更新日期：2020-03-06 00:00:00

abstract：:Cardiac hypertrophy, a response of the heart to increased workload, is a major risk factor for heart failure. Myostatin (MSTN) is an inhibitor of myogenesis, regulating the number and size of skeletal myocytes. In recent years, cardiomyocyte autophagy also has been considered to be involved in controlling the hypertro...

journal_title：Molecular therapy. Nucleic acids

authors： Qi H,Ren J,Ba L,Song C,Zhang Q,Cao Y,Shi P,Fu B,Liu Y,Sun H

更新日期：2020-03-06 00:00:00

abstract：:Retinoic acid-inducible gene-I (RIG-I) is a cytosolic pathogen sensor that is crucial against a number of viral infections. Many viruses have evolved to inhibit pathogen sensors to suppress host innate immune responses. In the case of influenza, nonstructural protein 1 (NS1) suppresses RIG-I function, leading to viral...

journal_title：Molecular therapy. Nucleic acids

authors： Singh N,Ranjan P,Cao W,Patel J,Gangappa S,Davidson BA,Sullivan JM,Prasad PN,Knight PR,Sambhara S

更新日期：2020-03-06 00:00:00

abstract：:As a diverse and abundant class of endogenous RNAs, circular RNAs (circRNAs) participate in processes including cell proliferation and apoptosis. Nevertheless, few researchers have investigated the function of circRNAs in bovine muscle development. Based on existing sequencing data, we identified circINSR. The localiz...

journal_title：Molecular therapy. Nucleic acids

authors： Shen X,Zhang X,Ru W,Huang Y,Lan X,Lei C,Chen H

更新日期：2020-03-06 00:00:00

abstract：:Besides the acquisition of pharmacokinetic parameters of antisense oligonucleotide microRNA (miRNA) inhibitors, such as measuring in vivo concentration, their pharmacodynamic characteristics are also of interest. An emerging and straightforward method for studying molecular interactions is microscale thermophoresis (M...

journal_title：Molecular therapy. Nucleic acids

authors： Herkt M,Batkai S,Thum T

更新日期：2019-12-06 00:00:00

abstract：:Deletion and mutation of the Smad4 gene are favorable events for the progression of colon cancer, which is related to the negative regulation of vascular endothelial growth factor C (VEGF-C). However, the regulatory mechanism between Smad4 and VEGF-C remains unclear. We reported first that Smad4 can increase the trans...

journal_title：Molecular therapy. Nucleic acids

authors： Li X,Lv X,Li Z,Li C,Li X,Xiao J,Liu B,Yang H,Zhang Y

更新日期：2019-12-06 00:00:00

abstract：:5-methylcytosine (m5C) is one of the most common and abundant post-transcriptional modifications (PTCMs) in RNA. Recent studies showed that m5C plays important roles in many biological functions such as RNA metabolism and cell fate decision. Because most experimental methods that determine m5C sites across the transcr...

journal_title：Molecular therapy. Nucleic acids

authors： Fang T,Zhang Z,Sun R,Zhu L,He J,Huang B,Xiong Y,Zhu X

更新日期：2019-12-06 00:00:00

abstract：:Menin displays either tumor suppression or promotion functions in a context-dependent manner. Previously, we proposed that Menin acts as a tumor suppressor by inhibiting cell growth in pancreatic ductal adenocarcinoma (PDAC), whereas the relationship between the Menin expression and overall survival rate of PDAC patie...

journal_title：Molecular therapy. Nucleic acids

authors： Cheng P,Chen Y,He TL,Wang C,Guo SW,Hu H,Ni CM,Jin G,Zhang YJ

更新日期：2019-12-06 00:00:00

abstract：:Mitochondrial DNA (mtDNA) haplogroups are associated with various types of cancer; however, the molecular mechanisms by which mtDNA haplogroups affect primary hepatocellular carcinoma (HCC) are not known. In this study, we carried out a case-control study on 388 HCC patients and 511 geographically matched asymptomatic...

journal_title：Molecular therapy. Nucleic acids

authors： Hua S,Li M,Zhao Q,Wang J,Zhou Y,Liu J,Fang H,Jiang M,Shen L

更新日期：2019-12-06 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder that causes acute respiratory failure, thus leading to relative high mortality worldwide. However, the molecular mechanisms of ALI remain largely unknown. MicroRNA (miRNA)-dependent control of gene expression at a post-transcriptional level has been recently reported. He...

journal_title：Molecular therapy. Nucleic acids

authors： Ying Y,Mao Y,Yao M

更新日期：2019-12-06 00:00:00

abstract：:Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as mRNAs and microRNAs (miRNAs), between different cells. Mesenchymal stem cells (MSCs) are able to migrate to the tumor sites and exert complex functions over tumor progress. We investigated the effect of human bone marrow-derived MSC (BMSC...

journal_title：Molecular therapy. Nucleic acids

authors： Che Y,Shi X,Shi Y,Jiang X,Ai Q,Shi Y,Gong F,Jiang W

更新日期：2019-12-06 00:00:00

abstract：:Upregulation of long non-coding RNA LINC00963 has been observed in several cancer types. In this study, we analyzed the clinical and biological significance of LINC00963 in breast cancer. The key microRNA (miR) mediating the action of LINC00963 was identified. We show that LINC00963 upregulation is correlated with agg...

journal_title：Molecular therapy. Nucleic acids

authors： Zhang N,Zeng X,Sun C,Guo H,Wang T,Wei L,Zhang Y,Zhao J,Ma X

更新日期：2019-12-06 00:00:00

abstract：:Schistosoma japonicum eggs trapped in host liver secretes microRNA (miRNA)-containing extracellular vesicles (EVs) that can be transferred to host cells. Recent studies demonstrated that miRNAs derived from plants can modulate gene expression and phenotype of mammalian cells in a cross-kingdom manner. In this study, w...

journal_title：Molecular therapy. Nucleic acids

authors： Lin Y,Zhu S,Hu C,Wang J,Jiang P,Zhu L,Li Z,Wang S,Zhang Y,Xu X,Pan W

更新日期：2019-12-06 00:00:00

abstract：:Selenium deficiency has been proven to induce calcium disorders in the chicken heart. However, detailed regulatory mechanisms, e.g., the long noncoding RNA (lncRNA)-microRNA (miRNA)-mRNA regulatory axis, have not yet been described. Here, we point out lnc-2315, miR-1594, and Troponin T (TNNT2) based on the results of ...

journal_title：Molecular therapy. Nucleic acids

authors： Yang J,Gong Y,Cai J,Liu Q,Zhang Z

更新日期：2019-12-06 00:00:00

abstract：:Osteoarthritis (OA) is the most common degenerative joint disease. One of the main pathogenic factors of OA is thought to be inflammation. Other factors associated with OA are dysregulation of microRNAs, reduced autophagic activity, oxidative stress, and altered metabolism. microRNAs are small non-coding RNAs that are...

journal_title：Molecular therapy. Nucleic acids

authors： Al-Modawi RN,Brinchmann JE,Karlsen TA

更新日期：2019-09-06 00:00:00

abstract：:Septic shock with heart dysfunction is very common in intensive care units. However, whether long noncoding RNA (lncRNA) and mRNA profiles differ between patients with and without myocardial depression is unknown. We generated rat models of hypodynamic septic shock induced by lipopolysaccharide. A total of 12 rat mode...

journal_title：Molecular therapy. Nucleic acids

authors： Zhang TN,Goodwin JE,Liu B,Li D,Wen R,Yang N,Xia J,Zhou H,Zhang T,Song WL,Liu CF

更新日期：2019-09-06 00:00:00

abstract：:Base editing systems show their power in modeling and correcting the pathogenic mutations of genetic diseases. Previous studies have already demonstrated the editing efficiency of BE3-mediated C-to-T conversion in human embryos. However, the precision and efficiency of a recently developed adenine base editor (ABE), w...

journal_title：Molecular therapy. Nucleic acids

authors： Li G,Liu X,Huang S,Zeng Y,Yang G,Lu Z,Zhang Y,Ma X,Wang L,Huang X,Liu J

更新日期：2019-09-06 00:00:00

abstract：:Increased propensity of bone marrow-derived mesenchymal stem cells (BM-MSCs) toward adipogenic differentiation has been implicated in the fatty bone marrow and defective hematopoiesis of aplastic anemia (AA). However, the underlying molecular mechanism remains to be investigated. In this study, we found that microRNA ...

journal_title：Molecular therapy. Nucleic acids

authors： Zhang X,Liu L,Dou C,Cheng P,Liu L,Liu H,Ren S,Wang C,Jia S,Chen L,Zhang H,Chen M

更新日期：2019-09-06 00:00:00

abstract：:Currently, the most effective and durable therapeutic option for HIV-1 infection is combination antiretroviral therapy (cART). Although cART is powerful and can delay viral evolution of drug resistance for decades, it is associated with limitations, including an inability to eradicate the virus and a potential for adv...

journal_title：Molecular therapy. Nucleic acids

authors： Takahashi M,Li H,Zhou J,Chomchan P,Aishwarya V,Damha MJ,Rossi JJ

更新日期：2019-09-06 00:00:00

abstract：:Circular RNA (circRNA) is a novel subclass of noncoding-RNA molecules that participate in development and progression of a variety of human diseases via sponging microRNAs (miRNAs), but the role of circRNAs in Hashimoto's thyroiditis (HT) has not been defined. In this study, peripheral blood samples from five patients...

journal_title：Molecular therapy. Nucleic acids

authors： Xiong S,Peng H,Ding X,Wang X,Wang L,Wu C,Wang S,Xu H,Liu Y

更新日期：2019-09-06 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell differentiation program is crucial to the bone microenvironment and bone development. MicroRNAs (miRNAs) have played a critical role in regulati...

journal_title：Molecular therapy. Nucleic acids

authors： Li Y,Yang F,Gao M,Gong R,Jin M,Liu T,Sun Y,Fu Y,Huang Q,Zhang W,Liu S,Yu M,Yan G,Feng C,He M,Zhang L,Ding F,Ma W,Bi Z,Xu C,Yuan Y,Cai B,Yang L

更新日期：2019-09-06 00:00:00

abstract：:Peritoneal fibrosis and loss of transport function is a common complication contributing to adverse outcomes in patients on long-term peritoneal dialysis (PD). Epithelial-to-mesenchymal transition (EMT) in mesothelial cells is a salient feature, but its triggering mechanisms remain obscure. Dysregulation of microRNA (...

journal_title：Molecular therapy. Nucleic acids

authors： Chu JYS,Chau MKM,Chan CCY,Tai ACP,Cheung KF,Chan TM,Yung S

更新日期：2019-09-06 00:00:00

abstract：:The role of microglia in the pathophysiology of ischemic retinal diseases has been studied extensively. Exosomes from microglial cells exert protective effects during several nervous system diseases, but their roles in hypoxia-induced retinopathy remain unclear. In our study, exosomes derived from microglial cells wer...

journal_title：Molecular therapy. Nucleic acids

authors： Xu W,Wu Y,Hu Z,Sun L,Dou G,Zhang Z,Wang H,Guo C,Wang Y

更新日期：2019-06-07 00:00:00

abstract：:A number of studies have reported that aberrant expression of microRNAs (miRNAs) closely correlates with the bone metastasis of prostate cancer (PCa). However, clinical significance and functional roles of both strands of a single miRNA in bone metastasis of PCa remain undefined. Here, we reported that miR-582-3p and ...

journal_title：Molecular therapy. Nucleic acids

authors： Huang S,Zou C,Tang Y,Wa Q,Peng X,Chen X,Yang C,Ren D,Huang Y,Liao Z,Huang S,Zou X,Pan J

更新日期：2019-06-07 00:00:00

abstract：:The human proinsulin gene (INS) contains a thymine-to-adenine variant (rs689) located in the 3' splice site (3' ss) recognition motif of the first intron. The adenine at rs689 is strongly associated with type 1 diabetes. By weakening the polypyrimidine tract, the adenine allele reduces the efficiency of intron 1 splic...

journal_title：Molecular therapy. Nucleic acids

authors： Lages A,Proud CG,Holloway JW,Vorechovsky I

更新日期：2019-06-07 00:00:00

abstract：:Bacteria with multiple drug resistance (MDR) have become a global issue worldwide, and hundreds of thousands of people's lives are threatened every year. The emergence of novel MDR strains and insufficient development of new antimicrobial agents are the major reasons that limit the choice of antibiotics for the treatm...

journal_title：Molecular therapy. Nucleic acids

authors： Law COK,Huang C,Pan Q,Lee J,Hao Q,Chan TF,Lo NWS,Ang IL,Koon A,Ip M,Chan E,Lau TCK

更新日期：2019-06-07 00:00:00

abstract：:A hexanucleotide GGGGCC expansion in intron 1 of chromosome 9 open reading frame 72 (C9orf72) gene is the most frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The corresponding repeat-containing sense and antisense transcripts cause a gain of toxicity through the accumulation o...

journal_title：Molecular therapy. Nucleic acids

authors： Martier R,Liefhebber JM,García-Osta A,Miniarikova J,Cuadrado-Tejedor M,Espelosin M,Ursua S,Petry H,van Deventer SJ,Evers MM,Konstantinova P

更新日期：2019-06-07 00:00:00

abstract：:Targeted transcriptional modulation in the central nervous system (CNS) can be achieved by adeno-associated virus (AAV) delivery of CRISPR activation (CRISPRa) and interference (CRISPRi) transgenes. To enable AAV packaging, we constructed minimal CRISPRa and CRISPRi transgenes by fusing catalytically inactive Staphylo...

journal_title：Molecular therapy. Nucleic acids

authors： Lau CH,Ho JW,Lo PK,Tin C

更新日期：2019-06-07 00:00:00

abstract：:Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) are deeply involved in the development of various cancers. This study identified that SBF2-AS1, an early-stage-specific lncRNA, is critical for the tumorigenesis of lung adenocarcinoma (LUAD). We first analyzed LUAD transcriptome data from The Cancer G...

journal_title：Molecular therapy. Nucleic acids

authors： Chen R,Xia W,Wang S,Xu Y,Ma Z,Xu W,Zhang E,Wang J,Fang T,Zhang Q,Dong G,Cho WC,Ma PC,Brandi G,Tavolari S,Ujhazy P,Metro G,Popper HH,Yin R,Qiu M,Xu L

更新日期：2019-06-07 00:00:00

abstract：:Emerging evidence has demonstrated that miR-223 is critically involved in the progression of pancreatic cancer (PC); however, the underlying mechanisms are not fully elucidated. In the present study, we explored the molecular basis of miR-223-mediated tumor progression in PC. We performed numerous approaches including...

journal_title：Molecular therapy. Nucleic acids

authors： Ma J,Cao T,Cui Y,Zhang F,Shi Y,Xia J,Wang ZP

更新日期：2019-03-01 00:00:00

abstract：:As the human lifespan has increased due to developments in medical technology, the number of patients with neurological diseases has rapidly increased. Therefore, studies on effective treatments for neurological diseases are becoming increasingly important. To perform these studies, it is essential to obtain a large n...

journal_title：Molecular therapy. Nucleic acids

authors： Daekee K,Mi-Jung H,Minjun J,Hee-Jin A,Kwang-Won S,Kyung-Sun K

更新日期：2019-03-01 00:00:00

abstract：:Following tendon injury, the development of fibrotic healing response impairs tendon function and restricts tendon motion. Peritendinous tissue fibrosis poses a major clinical problem in hand surgery. Communication between macrophages and tendon cells has a critical role in regulating the tendon-healing process. Yet, ...

journal_title：Molecular therapy. Nucleic acids

authors： Cui H,He Y,Chen S,Zhang D,Yu Y,Fan C

更新日期：2019-03-01 00:00:00